If you are talking about the current medicine practice in the ENTIRE world, its the entire body got pain relief, no distinguish.
For example, the tooth hurt, You can take the pain killer, or the birds they did this ancient medicine where the pain stop immediately, the pain killer patched, that is the regional apply the "external medicine", so the pain immediately relief.
The synthetical method will be you waiting about 10 mins, at least. Or you gone to the hospital, they inject into your blood stream.
What is the difference?
One is the external application of the patches.
One is the internal medicine, you intake it down through your throat.
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